AMG-208 Inhibitor CAS No. 1002304-34-8

Cat. No.	Name	Size	Price
KI2800	AMG-208	5 mg	$320
	AMG-208	10 mg	$512
	AMG-208	20 mg	$818
	AMG-208	50 mg	$1552
	AMG-208	100 mg	$2482
	AMG-208	200 mg	$3952
	AMG-208	1 g	$14960

Chemical Characteristic

Product Name	AMG-208
CAS No.	1002304-34-8
Molecular Weight	383.4
Formula	C₂₂H₁₇N₅O₂
Chemical Name	7-Methoxy-4-[(6-phenyl-1,2,4-triazolo[4,3-b]pyridazin-3-yl)methoxy]quinoline
Smiles	n1ccc(c2ccc(cc12)OC)OCc1n2c(ccc(n2)c2ccccc2)nn1
Chemical Structure

Biological activities

AMG 208 is a potent and selective inhibitor of kinase c-Met. The IC50 of AMG 208 against kinase c-Met is 9 nM. AMG-208 also inhibits HGF-mediated c-Met phosphorylation in PC3 cells with an IC50 of 46 nM. In vivo, in male Sprague-Dawley rats, AMG-208 (0.5 mg/kg i.v.) shows a high bioavailability with Cl of 0.37 L/h/kg, Vss of 0.38 L/kg and T1/2 of 1 hour.^[1]

Protocols

In vivo, AMG 208 is dissolved in DMSO.^[1]

References

[1]Albrecht BK, et al. Discovery and optimization of triazolopyridazines as potent and selective inhibitors of the c-Met kinase. J Med Chem. 2008, 51 (10): 2879-2882.

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