Cat. No. Name Size Price Add Cart
KI2391NSC63283910 mg$286
NSC63283950 mg$962

Chemical Characteristic

Product NameNSC632839
SynonymsN/A
CAS No.157654-67-6
Molecular Weight 339.86
FormulaC21H21NO.HCl
Chemical Name3,5-Bis[(4-methylphenyl)methylene]-4-piperidone hydrochloride
SmilesN1C/C(=C\c2ccc(cc2)C)/C(=O)/C(=C/c2ccc(cc2)C)/C1 Cl
Chemical Structure

Biological activities

NSC632839 is a pan-specific ubiquitin and ubiquitin-like isopeptidase inhibitor. NSC632839 inhibits ubiquitin-dependent proteolysis system 2 (UPS2), USP7, and SENP2 with IC50s of 45, 37 and 9.8 μM, respectively.[1]

References

[1] Eldridge AG, et al. Therapeutic strategies within the ubiquitin proteasome system. Cell Death Differ. 2010, 17(1): 4-13.

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