Oxaliplatin Inhibitor CAS No. 61825-94-3

Cat. No.	Name	Size	Price
KI4353	Oxaliplatin	50 mg	$120
	Oxaliplatin	100 mg	$204
	Oxaliplatin	200 mg	$358

Chemical Characteristic

Product Name	Oxaliplatin
Synonyms	Eloxatin
CAS No.	61825-94-3
Molecular Weight	397.29
Formula	C₈H₁₄N₂O₄Pt
Smiles	C1CC[C@H](C(C1)N)N [Pt]1OC(=O)C(=O)O1
Chemical Structure

Biological activities

Eloxatin is a third-generation analog of platinum compound with 1, 2- diaminocyclo-hexane carrier ligand. Eloxatin shows antitumoral activity in a wide variety of tumors such as ovarian, non-small-cell lung, breast cancer and non-Hodgkin?? lymphoma. Eloxatin inhibits KB and Hep2 cell lines with IC50 of 93.1 and 184.6 µM, respectively. ^[1] Eloxatin inhibits SW620 colon cancer cell viability with an IC50 of 88.6 ng/mL.^[2] Eloxatin inhibits 3T3-mock cells and 3T3-Abl⁺ cells with IC50 of 8.5 and 8.3 µM, respectively. ^[3] Eloxatin has similar mechanisms of action as cisplatin and mediates through formation of DNA adducts. Treatment of eloxatin for 2 hours can inhibit cell survival of S1 human colon cancer cells with an IC50 of 4.0 µM. ^[4]

Protocols

Eloxatin is dissolved in 25 mL of water for injection. ^[2]

References

[1] Espinosa M, et al. Oxaliplatin activity in head and neck cancer cell lines. Cancer Chemother Pharmacol. 2005, 55(3): 301-305. [2] Hahnvajanawong C, et al. Comparative Cytotoxic Activity of Oxitan and Eloxatin in Colon Cancer Cell Line SW620. Thai J Pharmacol. 2006, 28: 3. [3] Nehm? A, et al. Induction of JNK and c-Abl signalling by cisplatin and oxaliplatin in mismatch repair-proficient and -deficient cells. Br J Cancer. 1999, 79(7-8): 1104-1110. [4] Kjellstr?m J, et al. In vitro radiosensitization by oxaliplatin and 5-fluorouracil in a human colon cancer cell line. Acta Oncol. 2005, 44(7): 687-693.

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