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Cat. No. Name Size Price Add Cart
KI2368PRT062607 (P505-15, BIIB057) HCl5 mg$332
PRT062607 (P505-15, BIIB057) HCl25 mg$1114

Chemical Characteristic

Product NamePRT062607 (P505-15, BIIB057) HCl
SynonymsN/A
CAS No.1370261-97-4
Molecular Weight 429.91
FormulaC19H23N9O.HCl
Chemical Name4-((3-(2H-1,2,3-triazol-2-yl)phenyl)amino)-2-(((1R,2R)-2-aminocyclohexyl)amino)pyrimidine-5-carboxamide hydrochloride
Smilesc1(nc(c(cn1)C(=O)N)Nc1cc(ccc1)n1nccn1)NC1[C@H](CCCC1)N Cl
Chemical Structure

Biological activities

PRT062607 is a novel, highly selective, and orally bioavailable small molecule spleen tyrosine kinase (SYK) inhibitor with an IC50 of 1 nM. PRT062607 inhibits SYK-mediated B-cell receptor (BCR) signaling and decreases cell viability in non-Hodgkin lymphoma (NHL) and chronic lymphocytic leukemia (CLL).[1] In human whole blood, PRT062607 potently inhibits BCR-mediated B cell signaling and activation with IC50s of 0.27 and 0.28 mM, respectively. PRT062607 inhibits Fcε receptor 1 (FcεRI) -mediated basophil de-granulation with an IC50 of 0.15 mM.[2] Oral administration of PRT062607 in mice prevents BCR-mediated splenomegaly and significantly inhibits NHL tumor growth in a xenograft model.[1]

References

[1] Spurgeon SE, et al. The selective SYK inhibitor P505-15 (PRT062607) inhibits B cell signaling and function in vitro and in vivo and augments the activity of fludarabine in chronic lymphocytic leukemia. J Pharmacol Exp Ther. 2013, 344(2): 378-387.
[2] Coffey G, et al. Specific inhibition of spleen tyrosine kinase suppresses leukocyte immune function and inflammation in animal models of rheumatoid arthritis. J Pharmacol Exp Ther. 2012, 340(2): 350-359.

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KareBayTM provides scientists and clinicians with a wide range of biotechnological products and science lab supplies for chemical research and analyzing life processes. KareBay's extensive capabilities include commercializing reagents and kits, manufacturing biotech products and providing contract research services to organizations worldwide. Our many global labs, offices, and business partners enable KareBay to extend its products and services to its customer base around the world.

Our products are used for research, laboratory and further evaluation purposes. They are not for human use.
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