Home
Services
Organic Synthesis
Peptide Synthesis
Antibody Production
Protein Expression
Bioconjugation Service
Immunoassay Service
Molecular Biology Services
Oligonucleotides Synthesis
RNA Synthesis Service
Polymers & Contract Manufacturing
cGMP Peptide Synthesis Services
cGMP Organic Synthesis Services
Products
Small Molecule Inhibitors and Antagonist
Bioactive Compounds and Agonist
Primary Antibodies
Catalog Peptides
Amino Acids Derivatives
Reagents
Fluorescent dyes
Intermediates
PCR
Proteasomes and Enzymes
Enzyme substrate
Nucleotides
Promotions
Customer Support
About Us
Site Map
Contact Us
Small Molecule Inhibitors and Antagonist
Anti-virus
Cell Cycle
DMPK/Tox
Endocrinology
Epigenetics
GPCR/G-protein
Mitogen-activated Protein Kinases (MAPK)
PI3K/Akt/mTOR
Proteases/Proteasome
Protein Tyrosine Kinases (PTK)
Stem Cells
TGF-Beta/Smad
Transporter
Others
Cat. No. Name Size Price Add Cart
KI3285SB-225002QuoteQuote

Chemical Characteristic

Product NameSB-225002
CAS No.182498-32-4
Molecular Weight 352.14
FormulaC13H10BrN3O4
Chemical Structure

Biological activities

SB-225002 is a potent, selective non-peptide CXCR2 antagonist. SB-225002 inhibits 125I-IL-8 binding to CXCR2 with an IC50 of 22 nM. However, SB 225002 displays >150-fold selectivity over CXCR1. In 3ASubE cells stably transfected with CXCR2 in vitro, SB 225002 inhibits calcium mobilization induced by both GROα and IL-8 in a does-dependent manner, with IC50 values of 20 and 40 nM, respectively. In vitro, SB 225002 significantly inhibits human and rabbit neutrophil chemotaxis induced by both GROα and IL-8.[1] SB 225002 potently inhibits the proliferation of WHCO1 cells in vitro.[2] SB-225002 also inhibits HIV-1 replication in both T lymphocytes and macrophages in vitro.[3] In vivo, SB 225002 selectively blocks neutrophil margination induced by IL-8 in rabbits.[1] In vivo, curative treatment with SB 225002 also significantly ameliorates acute 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colitis in mice, along with the reduction of neutrophil influx, myeloperoxidase (MPO) activity, IL-1β, MIP-2, and keratinocyte-derived chemokine (KC) levels and the decreased expression of vascular endothelial growth factor (VEGF), inducible NO synthase (iNOS), and cyclooxygenase-2 (Cox-2) proteins into the colon tissue.[4]

Protocols

In vitro: SB-225002 is dissolved in dimethyl sulfoxide (DMSO).[5]

References

[1] White JR, et al. Identification of a potent, selective non-peptide CXCR2 antagonist that inhibits interleukin-8-induced neutrophil migration. J Biol Chem. 1998, 273(17): 10095-10098.
[2] Wang B, et al. A growth-related oncogene/CXC chemokine receptor 2 autocrine loop contributes to cellular proliferation in esophageal cancer. Cancer Res. 2006, 66(6): 3071-3077.
[3] Lane BR, et al. Interleukin-8 stimulates human immunodeficiency virus type 1 replication and is a potential new target for antiretroviral therapy. J Virol. 2001, 75(17): 8195-8202.
[4] Bento AF, et al. The selective nonpeptide CXCR2 antagonist SB225002 ameliorates acute experimental colitis in mice. J Leukoc Biol. 2008, 84(4): 1213-1221.
[5] Steude J, et al. Interleukin-1-stimulated secretion of interleukin-8 and growth-related oncogene-alpha demonstrates greatly enhanced keratinocyte growth in human raft cultured epidermis. J Invest Dermatol. 2002, 119(6): 1254-1260.

Please click here to fill online order form, and we will make sure to supply you product with detail information. This process usually takes between 24 to 48 hours, depending on products stock avaliability. All inquires and subsequent projects are handled in the strictest confidence and will be backed by a confidentiality agreement if required.
KareBayTM provides scientists and clinicians with a wide range of biotechnological products and science lab supplies for chemical research and analyzing life processes. KareBay's extensive capabilities include commercializing reagents and kits, manufacturing biotech products and providing contract research services to organizations worldwide. Our many global labs, offices, and business partners enable KareBay to extend its products and services to its customer base around the world.

Our products are used for research, laboratory and further evaluation purposes. They are not for human use.
About
KareBayTM Biochem
Sitemap
Blog
Custom Services
Organic Synthesis
Peptide Synthesis
Antibody Production
Protein Expression
Bioconjugation Service
Immunoassry Service
Molecular Biology Services
Oligonucleotides Synthesis
RNA Synthesis Service
cGMP Peptide Synthesis Services
cGMP Organic Synthesis Services
Biochemical Products
Small Molecule Inhibitors
Bioactive Compounds
Primary Antibodies
Peptides
Amino Acids
Reagents
Fluorescent dyes
Intermediates
PCR
Contact Us
KareBayTM Biochem, Inc.
11 Deer Park Drive, Suite 102A
Monmouth Junction, NJ 08852
Telephone
: 732-823-1545

Fax
: 732-823-1349
product@karebaybio.com
service@karebaybio.com
support@karebaybio.com
Follow Us
Follow Karebay on LinkedinFollow IMAGING on Twitter Google+ Facebook