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Cat. No. Name Size Price Add Cart
KI2718SU1481310 mg$650
SU1481350 mg$1430
SU14813100 mg$2548
SU14813200 mg$3770

Chemical Characteristic

Product NameSU14813
SynonymsSU-14813;SU 14813
CAS No.627908-92-3
Molecular Weight 442.48
FormulaC23H27FN4O4
Chemical Name5-[(Z)-(5-fluoro-2-oxo-1H-indol-3-ylidene)methyl]-N-[(2S)-2-hydroxy-3-morpholin-4-ylpropyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide
Smiles[nH]1c(c(c(c1/C=C/1\C(=O)Nc2c1cc(cc2)F)C)C(=O)NC[C@@H](CN1CCOCC1)O)C
Chemical Structure

Biological activities

SU14813 is a novel multiple receptor tyrosine kinase inhibitor. SU14813 has broad-spectrum RTK inhibitory activity through binding to and inhibition of VEGFR, PDGFR, KIT and FLT3.[1] SU14813 inhibits VEGFR-2, PDGFR-β, and FLT-3- internal tandem duplication phosphorylation with IC50s of 40, 20, and 50 nM, respectively.[2] In vivo, SU14813 shows broad and potent antitumor activity resulting in regression, growth arrest, or substantially reduced growth of various established xenograft cancer models,including gastrointestinal stromal tumor (GIST), renal cell carcinoma (RCC) and pancreatic neuroendocrine tumors in mice.[3]

Protocols

In vivo, SU14813 is dissolved in DMSO.[3]

References

[1] Patyna S, et al. SU14813: a novel multiple receptor tyrosine kinase inhibitor with potent antiangiogenic and antitumor activity. Mol Cancer Ther. 2006, 5 (7): 1774-1782.
[2] Prakash CR, et al. Indolinones as promising scaffold as kinase inhibitors: a review.Mini Rev Med Chem. 2012, 12 (2): 98-119.
[3] Hu-Lowe D, et al. The discovery and development of SU14813, a next-generation multitargeted tyrosine kinase inhibitor for the treatment of human malignancies. Mol Cancer Ther. 2011, 10 (11): 2015.

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