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KI2104TCS 40110 mg$358

Chemical Characteristic

Product NameTCS 401
SynonymsN/A
CAS No.243967-42-2
Molecular Weight 306.72
FormulaC10H10N2O5S.HCl
Chemical Name2-(carboxyformamido)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylic acid hydrochloride
SmilesC1c2c(CCN1)c(c(s2)NC(=O)C(=O)O)C(=O)O Cl
Chemical Structure

Biological activities

TCS 401 is a selective inhibitor of protein-tyrosine phosphatase 1B (PTP1B) with a Ki value of 290 nM. The Ki values of TCS 401 for CD45 D1D2 and PTPβ are 59 and 560 μM, respectively.[1]

References

[1] Iversen LF, et al. Structure-based design of a low molecular weight, nonphosphorus, nonpeptide, and highly selective inhibitor of protein-tyrosine phosphatase 1B. J Biol Chem. 2000, 275(14): 10300-10307.

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