Neuropeptides are small protein-like molecules which modulate neuronal communication by acting on cell surface receptors. They are involved in various brain functions, like analgesia, reward, food intake, metabolism, reproduction, social behaviors, learning and memory. Neuropeptides are secreted from neuronal cells and signal to neighboring cells. Many neuropeptides are co-released with other small-molecule neurotransmitters. Neuropeptides are synthesized by the enzymes such as prohormone convertases and carboxypeptidases that selectively cleave the peptide precursor at specific processing sites to generate the bioactive peptides.
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