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KKS0028Caspase-2 Inhibitor Drug Screening Kit (Fluorometric)100 assays$859.04

Overview

Product NameCaspase-2 Inhibitor Drug Screening Kit (Fluorometric)
Kit SummaryDetection method- Fluorescence (Ex/Em 380/500)
Applications- Effective means for screening caspase inhibitors using fluorometric methods
Features BenefitFast and convenient
Inhibition of caspase-2 activity can be determined by comparison of the fluorescence intensity in samples with and without the testing inhibitors
Kit Components2X Reaction Buffer
Caspase Substrate VDVAD-AFC (1 mM) DTT (1 M)
Active Caspase-2 (Lyophilized)
Caspase Inhibitor, Z-VAD-FMK (2 mM)
Storage Conditions-20
Shipping ConditionsGel back
DescriptionCaspases have been shown to play a crucial role in apoptosis induced by various deleterious and physiologic stimuli. Inhibition of caspases can delay apoptosis, implicating a potential role in drug screening efforts. The Caspase-2 Inhibitor Drug Screening Kit provides an effective means for screening caspase inhibitors using fluorometric methods. The assay utilizes synthetic peptide substrate VDVAD-AFC (AFC, 7-amino-4-trifluoromethyl coumarin). Active caspase-2 cleaves the synthetic substrate to release free AFC which can then be quantified by fluorometry. Compounds to be screened can directly be added to the reaction and the level of inhibition of caspase-2 activity can be determined by comparison of the fluorescence intensity in samples with and without the testing inhibitors.

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