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Cathepsin-e-inhibitor-screening-kit

Cat. No.	Name	Size	Price	Add Cart
KKS0065	Cathepsin E Inhibitor Screening Kit	100 assays	$1374.1

Overview

Product Name	Cathepsin E Inhibitor Screening Kit
Kit Summary	Detection method - Fluorescence Applications - Screen/study/characterize potential inhibitors of Cathepsin E
Features Benefit	Convenient & Rapid High-throughput adaptable assay to screen/study/characterize the potential inhibitors of Cathepsin E Cathepsin E inhibitor is included in the kit
Kit Components	CTSE Assay Buffer Human Cathepsin E CTSE Substrate CTSE Inhibitor (1 mM Pepstatin A in DMSO)
Storage Conditions	-20
Shipping Conditions	Gel back
Description	Cathepsin E (CTSE, EC3.4.23.34) is a gastric aspartyl protease that functions as a disulfide-linked homodimer. This protease has a specificity similar to that of pepsin A and cathepsin D. It is an intracellular proteinase that is found in highest concentration on the surface of epithelial mucus-producing cells of the stomach. It is the first aspartic proteinase expressed in the fetal stomach and is found in more than half of the gastric cancers. Cathepsin E Inhibitor Screening Kit utilizes the ability of Cathepsin E to cleave a synthetic AFC-based peptide substrate to release free AFC, which can be easily quantified using a fluorometer or fluorescence microplate reader. In the presence of a Cathepsin E-specific inhibitor, the cleavage of the substrate is reduced/abolished resulting in decrease or total loss of the AFC fluorescence. This simple and high-throughput adaptable assay kit can be used to screen/study/characterize the potential inhibitors of Cathepsin E.

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