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Cathepsin-h-inhibitor-screening-kit

Cat. No.	Name	Size	Price	Add Cart
KKS0066	Cathepsin H Inhibitor Screening Kit	100 assays	$1082.9

Overview

Product Name	Cathepsin H Inhibitor Screening Kit
Kit Summary	Detection method - Fluorescence Applications - Screen/study/characterize potential inhibitors of Cathepsin H
Features Benefit	Convenient & Rapid High-throughput adaptable assay to screen/study/characterize the potential inhibitors of Cathepsin H Cathepsin H inhibitor is included in the kit
Kit Components	CTSH Assay Buffer CTSH Reagent Human Cathepsin H CTSH Substrate CTSH Inhibitor (1 mM)
Storage Conditions	-20
Shipping Conditions	Gel back
Description	Cathepsin H (CTSH, EC 3.4.22.16), a lysosomal cysteine protease, is important in the overall degradation of lysosomal proteins. It is composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. The encoded protein, which belongs to the peptidase C1 protein family, can act both as an aminopeptidase and as an endopeptidase. Increased expression of this gene has been correlated with malignant progression of prostate tumors. Cathepsin H Inhibitor Screening Kit utilizes the ability of an active Cathepsin H to cleave a synthetic AFC-based peptide substrate to release free AFC, which can be easily quantified using a fluorometer or fluorescence microplate reader. In the presence of a Cathepsin H-specific inhibitor, the cleavage of this substrate is reduced/abolished resulting in decrease or total loss of the AFC fluorescence. This simple and high-throughput adaptable assay kit can be used to screen/study/characterize potential inhibitors of Cathepsin H.

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