Cat. No. Name Size Price Add Cart
KKS0067Cathepsin K Inhibitor Screening Kit100 assays$900.9

Overview

Product NameCathepsin K Inhibitor Screening Kit
Kit SummaryDetection method - Fluorescence
Applications - Screen/study/characterize potential inhibitors of Cathepsin K
Features BenefitSimple & convenient
High-throughput adaptable assay to screen/study/characterize the potential inhibitors of Cathepsin K
Cathepsin K inhibitor, FF-FMK is included in the kit
Kit ComponentsCTSK Reaction Buffer
CTSK Reagent
Cathepsin K (Human)
CTSK Substrate, Ac-LR-AFC (10 mM)
CTSK Inhibitor (FF-FMK, 1 mM)
Storage Conditions-20
Shipping ConditionsGel back
DescriptionCathepsin K (CTSK, EC 3.4.22.38), a lysosomal cysteine protease, is involved in osteoclastic bone remodeling and resorption. In addition, it also degrades collagen, gelatin and elastin. Cathepsin K Inhibitor Screening Kit utilizes the ability of active Cathepsin K to cleave the synthetic AFC based peptide substrate to release AFC, which can be easily quantified using a fluorometer or fluorescence microplate reader. In the presence of a Cathepsin K-specific inhibitor, the cleavage of this substrate is reduced/abolished resulting in decrease or total loss of the AFC fluorescence. This simple and high-throughput adaptable assay kit can be used to screen/study/characterize potential inhibitors of Cathepsin K.

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