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Hdac8-inhibitor-screening-kit-fluorometric

Cat. No.	Name	Size	Price	Add Cart
KKS0044	HDAC8 Inhibitor Screening Kit (Fluorometric)	100 assays	$846.3

Overview

Product Name	HDAC8 Inhibitor Screening Kit (Fluorometric)
Kit Summary	Detection method- Fluorescence (Em/Ex = 380/500 nm) Sample type- Testing candidate HDAC8 inhibitors Applications- Suitable for high throughput screening of HDAC-8 inhibitors
Features Benefit	Fast and convenient Kit contains the necessary reagents for testing putative HDAC-8 inhibitors
Kit Components	HDAC8 Assay Buffer HDAC8 Substrate HDAC8 Enzyme Developer Trichostatin A (2 uM in DMSO)
Storage Conditions	-20
Shipping Conditions	Gel back
Description	Histone deacetylases (HDACs) represent a large family of enzymes identified as key regulators of nucleosomal histone acetylation, a major event that controls eukaryotic gene transcription and are classified into three groups. They are believed to be involved in important biological activities, such as cell differentiation, proliferation, apoptosis, and senescence. In HDAC8 Inhibitor screening Kit, HDAC8 deacetylates the substrate (R-H-K(Ac)-K(Ac)-AFC) followed by an enzymatic cleavage to release the quenched fluorescent group (AFC), which can be detected at Em/Ex = 380/500 nm. In the presence of an HDAC-8 inhibitor, the deacetylation will be impeded which prevents the cleavage of the substrate to release AFC. The kit provides a rapid, simple, sensitive, and reliable test, which is also suitable for high throughput screening of HDAC8 inhibitors. Trichostatin A is included as a control inhibitor to compare the efficacy of the test inhibitors.

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Our products are used for research, laboratory and further evaluation purposes. They are not for human use.

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