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Mmp-1-inhibitor-screening-kit-fluorometric

Cat. No.	Name	Size	Price	Add Cart
KKS0096	MMP-1 Inhibitor Screening Kit (Fluorometric)	100 assays	$846.3

Overview

Product Name	MMP-1 Inhibitor Screening Kit (Fluorometric)
Kit Summary	Detection method-Fluorescence Sample type- Test inhibitors for MMP-1 Applications- The kit can be used to screen inhibitors of MMP-1
Features Benefit	Fast and convenient The assay is simple, reliable and ensures accuracy and consistency when working with multiple samples
Kit Components	Assay Buffer Substrate Inhibitor Control (5 uM GM 6001)
Storage Conditions	-20
Shipping Conditions	Gel back
Description	The Matrix metalloproteinase-1 (MMP-1, Interstitial collagenase, fibroblast collagenase) is a member of a multigene family of calcium-dependent, zinc-containing endoproteinases, the matrix metalloproteinases (MMPs). The MMPs are responsible for the degradation of the extracellular matrix (ECM) including collagens, elastins, gelatin, matrix glycoproteins and proteoglycan during normal development and disease processes. MMPs are regulated by hormones, growth factors and cytokines. MMP-1 belongs to the subclass, the collagenases, and along with MMP-8, and MMP-13 are the only members of the MMP family that are capable of degrading the types I, II and III interstitial collagens with high efficiency. These collagens are primarily found in bone, cartilage and skin. In MMP-1 Inhibitor Screening Kit, MMP-1 hydrolyzes a specific FRET substrate to release a quenched fluorescent group, which can be detected at Em/Ex =380/500nm. In presence of potent MMP-1 inhibitors the hydrolyzation of substrate will be inhibited or stopped. The kit provides a rapid, simple, sensitive, and reliable test suitable as a high throughput screening assay of MMP-1 inhibitors. For comparison of the relative efficacy of test inhibitors, a control inhibitor, GM 6001 (IC50 = 0.4 nM for MMP-1) is included.

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