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Cat. No. Name Size Price Add Cart
KP0135 360 MMP FRET Substrate III 1 mg $68

Product Information

Product Name360 MMP FRET Substrate III
Purity% Peak Area By HPLC ≥ 95%
Molecular Weight 1012.1
Storage-20°C
Sequence
(One-Letter Code)		Dnp-PLGMWSR
Sequence
(Three-Letter Code)		Dnp - Pro - Leu - Gly - Met - Trp - Ser - Arg - OH
DescriptionOptimized for both 72-kDa fibroblast gelatinase(MMP 2) and 92-kDa neutrophil gelatinase(MMP 9), this peptide substrate has the fluorescent Trp residue in subsite P'2 and the dinitrophenol (Dnp) quenching group on the N-terminus. The quenching of the Trp fluorescence in the intact substrate is relieved upon hydrolysis of the P1-P'1 bond, giving rise to a continuously recording fluorescence assay. The residues placed in subsites P3-P'1 and P'3 are optimized for MMP, while Arg is placed in P'4 to enhance solubility. The water solubility of this peptide substrate in assay buffer exceeds the Km value for the enzyme reaction, allowing accurate determination of the kinetic parameters. Abs/Em = 280/360 nm.
ReferencesRef: d'Ortho, MP. et al. Eur. J. Biochem. 250, 751 (1997); Netzel-Arnett, S. et al. Anal. Biochem. 195, 86 (1991).
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KareBayTM provides scientists and clinicians with a wide range of biotechnological products and science lab supplies for chemical research and analyzing life processes. KareBay's extensive capabilities include commercializing reagents and kits, manufacturing biotech products and providing contract research services to organizations worldwide. Our many global labs, offices, and business partners enable KareBay to extend its products and services to its customer base around the world.

Our products are used for research, laboratory and further evaluation purposes. They are not for human use.
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