Acadesine Inhibitor CAS No. 2627-69-2

Cat. No.	Name	Size	Price	Add Cart
KI0994	Acadesine	50 mg	$80
KI0994	Acadesine	200 mg	$272

Chemical Characteristic

Product Name	Acadesine
CAS No.	2627-69-2
Molecular Weight	258.23
Formula	C₉H₁₄N₄O₅
Chemical Name	5-amino-1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)-tetrahydrofuran-2-yl)-1H-imidazole-4-carboxamide
Smiles	c1nc(c([nH]1)N)C(=O)NC1[C@H](O)[C@H](O)[C@H](O1)CO
Chemical Structure

Biological activities

Acadesine is a cell-permeable AMP-activated protein kinase activator which is used for the treatment of acute lymphoblastic leukemia. Acadesine may have applications in treating other disorders such as diabetes. In vitro, acadesine (0-50 µM) inhibits lipopolysaccharide (LPS)-induced expression of proinflammatory cytokines (TGF-α, IL-1, and IL-6) and inducible nitric oxide synthase in primary rat astrocytes, microglia, and peritoneal macrophages. Acadesine attenuates the LPS-induced activation of nuclear factor κB via downregulation of IκB kinase α/β activity. Acadesine also inhibits the production of inflammatory mediators in serum and their expression in CNS of rats injected with a sublethal dose of LPS by intraperitoneal injection.^[1] Acadesine (0.01-0.5 mM) augments the proliferation, differentiation, and mineralization of wild-type MC3T3-E1 cells.^[2] Acadesine promotes NGF-induced neurite growth and reduces neurite outgrowth inhibition in PC-12 cells treated with astroglial conditioned medium.^[3]

References

[1] Giri S, et al. 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside inhibits proinflammatory response in glial cells: a possible role of AMP-activated protein kinase. J Neurosci. 2004, 24(2): 479-287. [2] Kanazawa I, et al. Adiponectin and AMP kinase activator stimulate proliferation, differentiation, and mineralization of osteoblastic MC3T3-E1 cells. BMC Cell Biol. 2007, 8:51. [3] Ayasolla KR, et al. 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside (AICAR) attenuates the expression of LPS- and Abeta peptide-induced inflammatory mediators in astroglia. J Neuroinflammation. 2005, 2:21. [4] Gali?anes M, et al. Acadesine and myocardial protection. Studies of time of administration and dose-response relations in the rat. Circulation. 1992??6(2): 598-608.

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