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Cat. No. Name Size Price Add Cart
KP0227 Alpha - Myosin (614 - 643) 1 mg $228

Product Information

Product NameAlpha - Myosin (614 - 643)
Purity% Peak Area By HPLC ≥ 95%
Molecular Weight 3047.5
Storage-20°C
Sequence
(One-Letter Code)		Ac-SLKLMATLFSTYASADTGDSGKGKGGKKKG
Sequence
(Three-Letter Code)		Ac - Ser - Leu - Lys - Leu - Met - Ala - Thr - Leu - Phe - Ser - Thr - Tyr - Ala - Ser - Ala - Asp - Thr - Gly - Asp - Ser - Gly - Lys - Gly - Lys - Gly - Gly - Lys - Lys - Lys - Gly - OH
DescriptionThis peptide belongs to the acetylated cardiac alpha-myosin amino acid residues 614 to 643. Immunization with cardiac myosin induces T cell-mediated myocarditis in genetically predisposed mice and serves as a model for autoimmune heart disease. The nonacetylated variant of this dominant peptide corresponding to amino acids 614 to 643 fails to induce the disease. N-terminal acetylation significantly changes the pathogenicity of the peptides. This acetylated form of the peptide shows dominant pathogenicity and induces severe myocarditis with inflammatory lesions throughout the ventricular wall.
ReferencesPummerer, C. et al. J. Clin. Invest. 97, 2057 (1996).
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KareBayTM provides scientists and clinicians with a wide range of biotechnological products and science lab supplies for chemical research and analyzing life processes. KareBay's extensive capabilities include commercializing reagents and kits, manufacturing biotech products and providing contract research services to organizations worldwide. Our many global labs, offices, and business partners enable KareBay to extend its products and services to its customer base around the world.

Our products are used for research, laboratory and further evaluation purposes. They are not for human use.
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