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Cat. No. Name Size Price Add Cart
KP0281 Aquaporin - 2 (254 - 267), pSER256, human 1 mg $122

Product Information

Product NameAquaporin - 2 (254 - 267), pSER256, human
Purity% Peak Area By HPLC ≥ 95%
Molecular Weight 1713.8
Storage-20°C
Sequence
(One-Letter Code)		RQ-pS-VELHSPQSLPR
Sequence
(Three-Letter Code)		H - Arg - Gln - pSer - Val - Glu - Leu - His - Ser - Pro - Gln - Ser - Leu - Pro - Arg - OH
DescriptionThis peptide is a fragment of the human aquaporin-2 (AQP2) phosphorylated at Ser256. Protein phosphorylation plays a key role in vasopressin signaling in the renal-collecting duct. AQP2 residues including S256 and S261, are altered in response to vasopressin. In the presence of vasopressin, AQP2 monophosphorylated at Ser256 and diphosphorylated AQP2 (pSer256/261) increase in abundance, whereas AQP2 monophosphorylated at Ser261 decreases, suggesting that both sites are involved in vasopressin-dependent AQP2 trafficking. Aquaporins are water channels. They form pores in the membranes of cells and selectively pass water molecules through the membrane, and prevent the crossing of sodium, potassium and other ions and small molecules.
ReferencesNielsen, S. et al. PNAS 90, 11663 (1993); Tajika, Y. et al. Endocrinol. 145, 4375 (2004); Hoffert, J. et al. PNAS 103, 7159 (2006).
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KareBayTM provides scientists and clinicians with a wide range of biotechnological products and science lab supplies for chemical research and analyzing life processes. KareBay's extensive capabilities include commercializing reagents and kits, manufacturing biotech products and providing contract research services to organizations worldwide. Our many global labs, offices, and business partners enable KareBay to extend its products and services to its customer base around the world.

Our products are used for research, laboratory and further evaluation purposes. They are not for human use.
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