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KP0401 Big Endothelin-1 (1-38), human 1 mg $376

Product Information

Product NameBig Endothelin-1 (1-38), human
Purity% Peak Area By HPLC ≥ 95%
Molecular Weight 4283
Storage-20°C
Sequence
(One-Letter Code)
CSCSSLMDKECVYFCHLDIIWVNTPEHVVPYGLGSPRS (Disulfide bridge: 1-15 and 3-11)
Sequence
(Three-Letter Code)
H-Cys-Ser-Cys-Ser-Ser-Leu-Met-Asp-Lys-Glu-Cys-Val-Tyr-Phe-Cys-His-Leu-Asp-Ile-Ile-Trp-Val-Asn-Thr-Pro-Glu-His-Val-Val-Pro-Tyr-Gly-Leu-Gly-Ser-Pro-Arg-Ser-OH (Disulfide bridge: 1-15 and 3-11)
DescriptionBig Endothelin-1 (1-38) is precursor of endothelin 1. Big endothelin-1 is cleaved to yield endothelin-1 via the activity of an endothelin-converting enzyme (ECE). Big Endothelin-1 can be hydrolyzed by chymase to generate endothelin 1 (1-21) in vitro. Endothelins are endothelium-derived vasoconstrictor peptides.
ReferencesFecteau; M. et al. Hypertension 46, 87 (2005).
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