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KP0554 Cathepsin K substrate 1 mg $265

Product Information

Product NameCathepsin K substrate
Purity% Peak Area By HPLC ≥ 95%
Molecular Weight 920
Storage-20°C
Sequence
(One-Letter Code)
Abz-HPGGPQ-EDDnp
Sequence
(Three-Letter Code)
Abz - His - Pro - Gly - Gly - Pro - Gln - EDDnp
DescriptionThis FRET peptide can be used to monitor selectively cathepsin K activity in physiological fluids and cell lysates. Abz-HPGGPQ-EDDnp [where Abz represents o-aminobenzoic acid and EDDnp represents N -(2,4-dinitrophenyl)-ethylenediamine], a substrate initially developed for trypanosomal enzymes, is efficiently cleaved at the Gly-Gly bond by cathepsin K. This peptide is resistant to hydrolysis by cathepsins B, F, H, L, S and V, Ex/Em=340 nm/420 nm.
ReferencesLecaille, F. et al. Biochem. J. 375, 307(2003).
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