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Cat. No. Name Size Price Add Cart
KP0642 CTT, Gelatinase Inhibitor 1 mg $110

Product Information

Product NameCTT, Gelatinase Inhibitor
Purity% Peak Area By HPLC ≥ 95%
Molecular Weight 1168.4
Storage-20°C
Sequence
(One-Letter Code)		CTTHWGFTLC (Disulfide Bridge: 1-10)
Sequence
(Three-Letter Code)		H - Cys - Thr - Thr - His - Trp - Gly - Phe - Thr - Leu - Cys - OH
DescriptionThis cyclic CTT Gelatinase Inhibitor peptide is an inhibitor for matrix metalloproteinases (MMP)-2 and MMP-9. It is also called type IV collagenase or gelatinase. Gelatinases are potential targets of therapeutic intervention in cancer, and inhibitors of these enzymes can prevent tumor progression. Cyclic CTT inhibits the migration of human endothelial cells and tumor cells. It prevents tumor growth and invasion. Inhibitors, complexed with their target proteinases, can be taken up into cells by endocytosis, and CTT added to liposomes enhances their uptake by tumor cells, thus providing possibility of liposomal delivery of chemotherapeutic agents. MMP-2 inhibition with cyclic CTT is also important in hypoxia studies.
ReferencesMedina, O. et al. Canc. Res. 61, 3978 (2001); He, J. et al. Am. J. Physiol. Heart. Circ. Physiol. 292, H684 (2007); Koivunen, E. et al. Nat. Biotech. 17, 768 (1999).
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KareBayTM provides scientists and clinicians with a wide range of biotechnological products and science lab supplies for chemical research and analyzing life processes. KareBay's extensive capabilities include commercializing reagents and kits, manufacturing biotech products and providing contract research services to organizations worldwide. Our many global labs, offices, and business partners enable KareBay to extend its products and services to its customer base around the world.

Our products are used for research, laboratory and further evaluation purposes. They are not for human use.
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