Cat. No. Name Size Price Add Cart
KP0687 E1, (E257) 1 mg $68

Product Information

Product NameE1, (E257)
Purity% Peak Area By HPLC ≥ 107%
Molecular Weight 1005.2
Storage-20°C
Sequence
(One-Letter Code)
EIINFEKL
Sequence
(Three-Letter Code)
H - Glu - Ile - Ile - Asn - Phe - Glu - Lys - Leu - OH
DescriptionThis peptide is an antagonist variant of OVA (257-264). It induces positive selection on the beta 2M (-/-), and negative selection on beta 2M (+/-) background. This peptide was used to study the ability of the wild-type or mutant TCRs to transduce signals leading to positive or negative selection, and was utilized in several thymocyte development studies. E1 presentation leads to Egr-1 induction and ERK phosphorylation.
ReferencesCanté-Barrett, K. et al. J. Immunol. 176, 2299 (2006); Worlen, G. et al. Nature 406, 422 (2000); Starr, T. et al. J. Immunol. 171, 4512 (2003).
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