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KP0691 EGF Receptor Substrate 2 [DADE - pY - LIPQQG], Biotinylated 1 mg $195

Product Information

Product NameEGF Receptor Substrate 2 [DADE - pY - LIPQQG], Biotinylated
Purity% Peak Area By HPLC ≥ 95%
Molecular Weight 1556.6
Storage-20°C
Sequence
(One-Letter Code)
Biotin-DADE-pY-LIPQQG
Sequence
(Three-Letter Code)
Biotin - Asp - Ala - Asp - Glu - pTyr - Leu - Ile - Pro - Gln - Gln - Gly - OH
DescriptionThe unlabeled phosphopeptide is an excellent substrate for mammalian protein tyrosine phosphatase 1B (Km = 3.9 µM) and Yersinia PTP. The sequence is derived from an autophosphorylation site (Tyr992) of EGFR. The unlabeled peptide is used to assay PTB based on marked fluorescence increase upon the removal of the phosphate group (Em = 305 nm and Ex = 282 nm).
ReferencesRef: Ukkola, O. and MJ. Santaniemi, Intern. Med. 251, 467 (2002); Sarmiento, M. et al. J. Biol. Chem. 273, 26368 (1998); Zhang, ZY. et al. Anal. Biochem. 211, 7 (1993).
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