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KP0702 Endothelin 1, human, porcine 1 mg $443

Product Information

Product NameEndothelin 1, human, porcine
Purity% Peak Area By HPLC ≥ 95%
Molecular Weight 2492
Storage-20°C
Sequence
(One-Letter Code)
CSCSSLMDKECVYFCHLDIIW (Disulfide bridge: 1-15 and 3-11)
Sequence
(Three-Letter Code)
H-Cys-Ser-Cys-Ser-Ser-Leu-Met-Asp-Lys-Glu-Cys-Val-Tyr-Phe-Cys-His-Leu-Asp-Ile-Ile-Trp-OH (Disulfide bridge: 1-15 and 3-11)
DescriptionET-1 is a potent vasoconstrictor peptide derived from endothelial cells. It plays a role in regulation of cardiovascular functions. The binding of ET-1 to G-protein coupled receptor triggers a signal transduction cascade leading to activation of the protein kinase C (PKC). PKC inhibitor potentially reverses the up regulation of ET-1. The enhanced ET-1 expression associated with the activation of PKC occurs in early diabetes.
ReferencesRef: Yanagisawa, M. et al. Nature. 332, 411 (1988).
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