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Cat. No. Name Size Price Add Cart
KP0848 Glutamic Acid Decarboxylase (GAD65) (524 - 543), p524 - 543 1 mg $116

Product Information

Product NameGlutamic Acid Decarboxylase (GAD65) (524 - 543), p524 - 543
Purity% Peak Area By HPLC ≥ 95%
Molecular Weight 2238.7
Storage-20°C
Sequence
(One-Letter Code)		SRLSKVAPVIKARMMEYGTT
Sequence
(Three-Letter Code)		H - Ser - Arg - Leu - Ser - Lys - Val - Ala - Pro - Val - Ile - Lys - Ala - Arg - Met - Met - Glu - Tyr - Gly - Thr - Thr - OH
DescriptionThis is amino acids 524 to 543 fragment of glutamic acid decarboxylase 65 (GAD65). It is one of the first fragments of this islet antigen to induce proliferative T cell responses in the non-obese diabetic (NOD) mouse model of spontaneous autoimmune diabetes. This peptide is a specific, possibly low affinity, stimulus for the spontaneously arising diabetogenic T cell clone BDC2.5. Immunization with p524-543 increases the susceptibility of the NOD mice to type 1 diabetes induced by the adoptive transfer of BDC2.5 T cells.
ReferencesQuinn, A. et al. J. Immunol. 166, 2982 (2001); Dai, Y. et al. J. Immunol. 175, 3621 (2005).
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KareBayTM provides scientists and clinicians with a wide range of biotechnological products and science lab supplies for chemical research and analyzing life processes. KareBay's extensive capabilities include commercializing reagents and kits, manufacturing biotech products and providing contract research services to organizations worldwide. Our many global labs, offices, and business partners enable KareBay to extend its products and services to its customer base around the world.

Our products are used for research, laboratory and further evaluation purposes. They are not for human use.
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