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KP0929 Hirudin (54-65) 1 mg $101

Product Information

Product NameHirudin (54-65)
Purity% Peak Area By HPLC ≥ 95%
Molecular Weight 1468.5
Storage-20°C
Sequence
(One-Letter Code)
GDFEEIPEEYLQ
Sequence
(Three-Letter Code)
H-Gly-Asp-Phe-Glu-Glu-Ile-Pro-Glu-Glu-Tyr-Leu-Gln-OH
DescriptionThis is amino acids 54 to 65 fragment of hirudin, a 65-residue peptide. Hirudin is found in the saliva of the leech Hirudo medicinalis. The unsulfated peptide corresponding to the C-terminal of hirudin has demonstrated efficacy in inhibiting clot formation in vitro. This hirudin fragment (desulfated) causes contraction of canine coronary arteries which is attenuated by calcium-channel blockers.
ReferencesSorajja, P. et al. J. Am. Coll. Cardiol. 31, 53 (1998); Krstenansky, J. L. FEBS Lett. 211, 10 (1987).
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