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Cat. No. Name Size Price Add Cart
KP0051 [Lys(Ac)382] - p53 (361 - 393), biotin labeled, amide, human 1 mg $399

Product Information

Product Name[Lys(Ac)382] - p53 (361 - 393), biotin labeled, amide, human
Purity% Peak Area By HPLC ≥ 95%
Molecular Weight 4034.7
Storage-20°C
Sequence
(One-Letter Code)		Biotin-LC-GSRAHSSHLKSKKGQSTSRHK-K(Ac)-LMFKTEGPDSD-NH2
Sequence
(Three-Letter Code)		Biotin - LC - Gly - Ser - Arg - Ala - His - Ser - Ser - His - Leu - Lys - Ser - Lys - Lys - Gly - Gln - Ser - Thr - Ser - Arg - His - Lys - Lys(Ac) - Leu - Met - Phe - Lys - Thr - Glu - Gly - Pro - Asp - Ser - Asp - NH2
DescriptionThis is an amidated peptide derived from residues 361-393 of human p53 tumor suppressor protein with acetylation at Lys382. This peptide is biotin-labeled at its N-terminus with a 6-carbon LC linker. Activated p53 functions to induce cell cycle arrest and apoptosis in response to signals such as DNA damage. Acetylation of p53 reduces ubiquitination by MDM2 and increases p53 half-life in vivo.
ReferencesKubbutat, M. et al. Lett Nature 387, 299 (1997); Li, M. et al. J Biol Chem 277, 50607 (2002).
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KareBayTM provides scientists and clinicians with a wide range of biotechnological products and science lab supplies for chemical research and analyzing life processes. KareBay's extensive capabilities include commercializing reagents and kits, manufacturing biotech products and providing contract research services to organizations worldwide. Our many global labs, offices, and business partners enable KareBay to extend its products and services to its customer base around the world.

Our products are used for research, laboratory and further evaluation purposes. They are not for human use.
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