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Cat. No. Name Size Price Add Cart
KP1156 MBP MAPK Substrate 1 mg $60

Product Information

Product NameMBP MAPK Substrate
Purity% Peak Area By HPLC ≥ 95%
Molecular Weight 967.1
Storage-20°C
Sequence
(One-Letter Code)		APRTPGGRR
Sequence
(Three-Letter Code)		H - Ala - Pro - Arg - Thr - Pro - Gly - Gly - Arg - Arg - OH
DescriptionThe sequence APRTPGGRR contains a native sequence derived from bovine myelin basic protein amino acids 95-98 (PRTP). The rest of the sequence is not derived from a native sequence, but is a synthetic construct. This substrate is specific for MAP kinases: p44MAPK [extracellular signal-regulated kinase 1 (ERK1)] and p42MAPK (ERK2). It contains the consensus sequence Pro-X-(Ser/Thr)-Pro that is recognized by MAP kinase. This peptide is the most efficient substrate for phosphorylation reaction by ERK. The substrate is phosphorylated by kinases on threonine 97 and can also be phosphorylated by MAPK p38.
ReferencesRef: Clark-Lewis, I. et al. J. Biol. Chem. 266, 15180 (1991); Nam, H. et al. J. Chromatogr A. 976, 79 ( 2002); Sommer, F. et al. Int. J. Impot. Res. 14, 217 (2002); Lents, NH. et al. Ann. N.Y. Acad. Sci. 973, 265 (2002); Kameshita, I. et al. J. Biochem. (Tokyo) 122, 168 (1997); Daeipour, M. et. al. J. Immunol. 150, 4743 (1993); Song, SJ. Neurosci. 18, 4119 (1998); Gerthoffer, W. et al. J. Physiol. 495, 597 (1996).
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KareBayTM provides scientists and clinicians with a wide range of biotechnological products and science lab supplies for chemical research and analyzing life processes. KareBay's extensive capabilities include commercializing reagents and kits, manufacturing biotech products and providing contract research services to organizations worldwide. Our many global labs, offices, and business partners enable KareBay to extend its products and services to its customer base around the world.

Our products are used for research, laboratory and further evaluation purposes. They are not for human use.
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