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Cat. No. Name Size Price Add Cart
KP0079 [NMeG24, NMeI26] Human Islet Amyloid Polypeptide (IAPP) (22 - 27) 1 mg $211

Product Information

Product Name[NMeG24, NMeI26] Human Islet Amyloid Polypeptide (IAPP) (22 - 27)
Purity% Peak Area By HPLC ≥ 95%
Molecular Weight 661.8
Storage-20°C
Sequence
(One-Letter Code)		NF-(NMe-G)-A-(NMe-I)-L
Sequence
(Three-Letter Code)		H - Asn - Phe - (NMe - Gly) - Ala - (NMe - Ile) - Leu - OH
DescriptionThis amino acids 22 to 27 fragment is a modification of the human islet amyloid polypeptide hIAPP (NFGAIL) with N-methylation of the amide bonds at G24 and I26. The introduction of two N-methyl rests in the amyloid-core-containing sequence NFGAIL converts this amyloidogenic and cytotoxic sequence into non-amyloidogenic and non-cytotoxic peptide. The peptide is able to bind with high-affinity full-length hIAPP and to inhibit its fibrillogenesis.
ReferencesYan, L. et al. PNAS 103, 2046 (2006), Kapurniotu, A., et al. J. Mol. Biol. 315, 339 (2002), Tatarek-Nossol, M. et al. Cell Press 12, 797 (2005).
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KareBayTM provides scientists and clinicians with a wide range of biotechnological products and science lab supplies for chemical research and analyzing life processes. KareBay's extensive capabilities include commercializing reagents and kits, manufacturing biotech products and providing contract research services to organizations worldwide. Our many global labs, offices, and business partners enable KareBay to extend its products and services to its customer base around the world.

Our products are used for research, laboratory and further evaluation purposes. They are not for human use.
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