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KP1272 NP - M2tide 1 mg $80

Product Information

Product NameNP - M2tide
Purity% Peak Area By HPLC ≥ 95%
Molecular Weight 1456.5
Storage-20°C
Sequence
(One-Letter Code)
GGAVDDDYAQFANGG
Sequence
(Three-Letter Code)
H - Gly - Gly - Ala - Val - Asp - Asp - Asp - Tyr - Ala - Gln - Phe - Ala - Asn - Gly - Gly - OH
DescriptionThis 15-mer peptide is derived from NP-M2tide, a peptide that is able to bind to human M2 isoform of pyruvate kinase (PKM2). PKM2 is a phosphotyrosine-binding protein, that once bound to phosphotyrosine peptides, will release fructose-1,6-biphosphate that will block the enzymatic activity of PKM2. This event veers glucose metabolites from energy production to anabolic processes. PKM2 is also crucial for rapid cancer cell growth.
ReferencesChristofk, H., et al. Nature, 452, 181 (2008).
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