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KP1278 Nuclear Factor (Erythroid - derived 2)like 2 (74 - 87); Nrf2 (74 - 87); NFE2L2 (74 - 87) 5 mg $269

Product Information

Product NameNuclear Factor (Erythroid - derived 2)like 2 (74 - 87); Nrf2 (74 - 87); NFE2L2 (74 - 87)
Purity% Peak Area By HPLC ≥ 95%
Molecular Weight 1631.8
Storage-20°C
Sequence
(One-Letter Code)
LQLDEETGEFLPIQ
Sequence
(Three-Letter Code)
H - Leu - Gln - Leu - Asp - Glu - Glu - Thr - Gly - Glu - Phe - Leu - Pro - Ile - Gln - OH
DescriptionThis peptide is derived from the Neh2 domain of nuclear factor (erythroid-derived 2)-like 2, or Nrf2. Nrf2 is a bZIP transcription factor that regulates the expression of antioxidative and cytoproptective genes. The DxETGE motif of this peptide binds Keap1 Kelch adaptor protein and displaces Nrf2 from Keap1.
ReferencesYokota, S. et al. Biochem Pharmacol 81, 289 (2011); Lo, S-C. et al. EMBO J 25, 3605 (2006).
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