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Cat. No. Name Size Price Add Cart
KP1380 PKC Substrate [RRGR-pT-GRGRRGIFR], Phosphorylated 5 mg $946

Product Information

Product NamePKC Substrate [RRGR-pT-GRGRRGIFR], Phosphorylated
Purity% Peak Area By HPLC ≥ 95%
Molecular Weight 1780.9
Storage-20°C
Sequence
(One-Letter Code)		RRGR-pT-GRGRRGIFR
Sequence
(Three-Letter Code)		H-Arg-Arg-Gly-Arg-pThr-Gly-Arg-Gly-Arg-Arg-Gly-Ile-Phe-Arg-OH
DescriptionThe native peptide, RRGRTGRGRRGIF, is proven to be a highly selective substrate for Protein Kinase C (PKC). It is based on the amino acid sequence 1487-1500 of the non-structural protein 3 of Hepatitis C virus (HCV). Substitution of Tyr1499 in HCV by Phe makes the peptide substrate more effectively phosphorylated by rat brain PKC (Km = 5µM) and mouse epidermal cell extracts (Km = 25 nM) than other kinases such as tyrosine kinases or other serine/threonine kinases. It is very useful for assaying PKC activity in the presence of other kinases in tissues and crude cell extracts.
ReferencesRef: Borowski, P. et al. J. Biol. Chem. 274, 30722 (1999).
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KareBayTM provides scientists and clinicians with a wide range of biotechnological products and science lab supplies for chemical research and analyzing life processes. KareBay's extensive capabilities include commercializing reagents and kits, manufacturing biotech products and providing contract research services to organizations worldwide. Our many global labs, offices, and business partners enable KareBay to extend its products and services to its customer base around the world.

Our products are used for research, laboratory and further evaluation purposes. They are not for human use.
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