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KP1425 Prosaptide TX14(A) 1 mg $95

Product Information

Product NameProsaptide TX14(A)
Purity% Peak Area By HPLC ≥ 95%
Molecular Weight 1579.7
Storage-20°C
Sequence
(One-Letter Code)
TaLIDNNATEEILY
Sequence
(Three-Letter Code)
H-Thr-D-Ala-Leu-Ile-Asp-Asn-Asn-Ala-Thr-Glu-Glu-Ile-Leu-Tyr-OH
DescriptionThis 14-mer prosaptide sequence is derived from the active neurotrophic region in the amino-terminal portion of the saposin C domain. Synthetic peptides derived from this region are biologically active and are named " prosaptides." Prosaposin and prosaptides are active on a variety of neuronal cells, stimulating sulfatide synthesis and increasing sulfatide concentration in Schwann cells and oligodendrocytes. This indicates that prosaposin and prosaptides are trophic factors for myelin formation.
ReferencesCampana, M. et al. FASEB J. 12, 307 (1998); Hiraiwa, M. et al. Proc. Natl. Acad. Sci. USA 94, 4778 (1997); Taylor, E. et al. Pharmacol. 295, 190 (2000); Calcutt, NA. et al. Anesthesiology 93, 1271 (2000).
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