Cat. No. Name Size Price Add Cart
KP1456 PrP (166 - 179), Protease - Resistant Prion Protein (166 - 179) (Biotin - LC), hamster 1 mg $116

Product Information

Product NamePrP (166 - 179), Protease - Resistant Prion Protein (166 - 179) (Biotin - LC), hamster
Purity% Peak Area By HPLC ≥ 95%
Molecular Weight 2049.3
Storage-20°C
Sequence
(One-Letter Code)
Biotin-LC-VDQYNNQNNFVHDC
Sequence
(Three-Letter Code)
Biotin - LC - Val - Asp - Gln - Tyr - Asn - Asn - Gln - Asn - Asn - Phe - Val - His - Asp - Cys - OH
DescriptionThis peptide potently inhibits the protease-resistant prion protein (PrP-res) induced cell-free conversion of protease-sensitive (PrP-sen) to the protease-resistant state. The formation of PrP-res involves selective interactions between PrP-res and its normal protease-sensitive counterpart, PrP-sen. The accumulation of the protease-resistant isoform of prion protein PrP-res in the central nervous system is the pre-eminent neuropathological feature of transmissible spongiform encephalopathies (TSEs), a fatal neurodegenerative disease. This inhibitory peptide may mimic contact surfaces between PrP-res and PrP-sen and thereby serve as model of potential therapeutic agent for transmissible spongiform encephalopathies. This peptide is biotinylated through 6-aminohexanoate (LC) as a spacer at the N-terminus.
ReferencesHoriuchi, M. et al. J. Biol. Chem. 276, 15489 (2001).
Please click here to fill online order form, and we will make sure to supply you product with detail information. This process usually takes between 24 to 48 hours, depending on products stock avaliability. All inquires and subsequent projects are handled in the strictest confidence and will be backed by a confidentiality agreement if required.
KareBayTM provides scientists and clinicians with a wide range of biotechnological products and science lab supplies for chemical research and analyzing life processes. KareBay's extensive capabilities include commercializing reagents and kits, manufacturing biotech products and providing contract research services to organizations worldwide. Our many global labs, offices, and business partners enable KareBay to extend its products and services to its customer base around the world.

Our products are used for research, laboratory and further evaluation purposes. They are not for human use.