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KP1497 Sarafotoxin 6c 1 mg $300

Product Information

Product NameSarafotoxin 6c
Purity% Peak Area By HPLC ≥ 95%
Molecular Weight 2515.8
Storage-20°C
Sequence
(One-Letter Code)
CTCNDMTDEECLNFCHQDVIW (Disulfide bridge: 1-15 and 3-11)
Sequence
(Three-Letter Code)
H-Cys-Thr-Cys-Asn-Asp-Met-Thr-Asp-Glu-Glu-Cys-Leu-Asn-Phe-Cys-His-Gln-Asp-Val-Ile-Trp-OH (Disulfide bridge: 1-15 and 3-11)
DescriptionThis selective ET receptor subtype B agonist is a vasoconstrictor peptide. In experiments on renal vasoconstrictor actions, sarafotoxin 6c appears to be potent at the renal resistance vasculature and is powerfully modulated by NO. It plays a role in cytosolic Ca2+ concentration ([Ca2+]i) balance.The differences between central helix of the endothelin and sarafotoxin isopeptides might be important in binding of these ligands by the G protein-coupled endothelin receptors.
ReferencesRef: Mills, R. et al. J. Biol. Chem. 269, 23413 (1994); Watanabe, C. et al. Br. J. Pharmacol. 108, 30 (1993); Marshall, JL. and JJ. Edward, Br. J. Pharmacol. 128, 809 (1999).
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