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Cat. No. Name Size Price Add Cart
KP1543 SmMLCKp, Smooth-Muscle Myosin Light-Chain Kinase (796-815), Calmodulin Binding 1 mg $116

Product Information

Product NameSmMLCKp, Smooth-Muscle Myosin Light-Chain Kinase (796-815), Calmodulin Binding
Purity% Peak Area By HPLC ≥ 95%
Molecular Weight 2278.7
Storage-20°C
Sequence
(One-Letter Code)		ARRKWQKTGHAVRAIGRLSS
Sequence
(Three-Letter Code)		H-Ala-Arg-Arg-Lys-Trp-Gln-Lys-Thr-Gly-His-Ala-Val-Arg-Ala-Ile-Gly-Arg-Leu-Ser-Ser-OH
DescriptionThis is amino acids 796 to 815 fragment of the chicken gizzard smooth-muscle myosin light-chain kinase (smMLCKp or P7) peptide, calmodulin (CaM)-binding domain . It retains its affinity for CaM and represents an adequate model for a complex of CaM with intact smMLCK protein. In the globular (Ca2+)4-CaM-P7 complex, the protein is wrapped around the -helical peptide. All the lysine and arginine charges of P7 are in close contact with the negatively charged side chains of the acidic residues of CaM. Calmodulin operates as a Ca2+ sensor and is known to interact with and regulate hundreds of proteins involved in many aspects of cellular function.
ReferencesFrederick, K. et al. Nature 448, 325 (2007); André. I. et al. Biophys. J. 90, 2903 (2006).
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Our products are used for research, laboratory and further evaluation purposes. They are not for human use.
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