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KP1556 Steroid Receptor Coactivator-1 (SRC-1), (676-700)-Lys(Biotin), amide 1 mg $291

Product Information

Product NameSteroid Receptor Coactivator-1 (SRC-1), (676-700)-Lys(Biotin), amide
Purity% Peak Area By HPLC ≥ 95%
Molecular Weight 3153.7
Storage-20°C
Sequence
(One-Letter Code)
CPSSHSSLTERHKILHRLLQEGSPS-K(Biotin)-NH2
Sequence
(Three-Letter Code)
H-Cys-Pro-Ser-Ser-His-Ser-Ser-Leu-Thr-Glu-Arg-His-Lys-Ile-Leu-His-Arg-Leu-Leu-Gln-Glu-Gly-Ser-Pro-Ser-Lys(Biotin)-NH2
DescriptionThis peptide is amino acids 676 to 700 fragment derived from the second LXXLL motif of steroid receptor coactivator (SRC1), modified with Lys(Biotin) coupled to the C-terminus. Coactivator proteins interact with nuclear receptors in a ligand-dependent manner and augment transcription. A short amphipathic alpha-helical domain that includes this LXXLL motif serves as the interaction interface between the coactivator molecules and the ligand-dependent activation function (AF-2) located in the C-terminus of the nuclear receptor ligand-binding domain (LBD). Receptor binding domain of the coactivator SRC-1 is specifically recruited to the farnesoid X receptor (FXR) ligand-binding domain.
ReferencesUrizar, N. et al. Science 296, 1703 (2002); Parks, D. et al. Science 284, 1365 (1999).
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