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Cat. No. Name Size Price Add Cart
KP1574 TACE FRET Substrate I(DABCYL - Leu - Ala - Gln - Ala - Val - Arg - Ser - Ser - Ser - Arg - EDANS) 1 mg $228

Product Information

Product NameTACE FRET Substrate I(DABCYL - Leu - Ala - Gln - Ala - Val - Arg - Ser - Ser - Ser - Arg - EDANS)
Purity% Peak Area By HPLC ≥ 95%
Molecular Weight 1573.6
Storage-20°C
DescriptionTACE FRET substrate I is derived from the cleavage sequence of pro-TNFa recognized by TNFa-cleaving enzyme (TACE). TNFa is presumably shed from cell membranes by TNFa-cleaving enzyme (TACE). Incubation of the TACE substrate with recombinant human TACE gives a specific cleavage to restore the quenched fluorescence. The substrate is widely used to screen inhibitors of TNF-convertase.Minimum Purity: 95%
ReferencesBecker BF, et al. (2002). Application of peptides containing the cleavage sequence of pro-TNFalpha in assessing TACE activity of whole cells. Biol Chem 383, 1821-6, Mohler KM, et al. (1994). Protection against a lethal dose of endotoxin by an inhibitor of tumour necrosis factor processing. Nature 370, 218-20
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KareBayTM provides scientists and clinicians with a wide range of biotechnological products and science lab supplies for chemical research and analyzing life processes. KareBay's extensive capabilities include commercializing reagents and kits, manufacturing biotech products and providing contract research services to organizations worldwide. Our many global labs, offices, and business partners enable KareBay to extend its products and services to its customer base around the world.

Our products are used for research, laboratory and further evaluation purposes. They are not for human use.
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