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KP1652 Transcriptional Intermediary Factor 2, Tif-2 (685-697) 1 mg $80

Product Information

Product NameTranscriptional Intermediary Factor 2, Tif-2 (685-697)
Purity% Peak Area By HPLC ≥ 95%
Molecular Weight 1616.9
Storage-20°C
Sequence
(One-Letter Code)
EKHKILHRLLQDS
Sequence
(Three-Letter Code)
H-Glu-Lys-His-Lys-Ile-Leu-His-Arg-Leu-Leu-Gln-Asp-Ser-OH
DescriptionThis 13-amino acid TIF2 peptide with a LxxLL motif is derived from the NR box2 region of TIF2 (SRC2?). A short consensus motif, so-called nuclear receptor (NR) box, mediates ligand-dependent activation interaction function between nuclear receptors and their coregulators. This TIF2 peptide fragment is sufficient to interact with thyroid hormone ligand binding domain, TR-beta- LBD.
ReferencesKong, E. et al. PNAS 102, 3593 (2005); Wärnmark, A., et al. J. Biol. Chem. 277, 21862 (2002); Darimont, B. et al. Genes Dev. 12, 3343 (1998).
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