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Bioactive Compounds and Agonist
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Cat. No. Name Size Price Add Cart
KI2573TUG89110 mg$403
TUG89150 mg$1609.4

Chemical Characteristic

Product NameTUG891
CAS No.1374516-07-0
Molecular Weight 364.41
FormulaC23H21FO3
Chemical Name3-{4-[(4-Fluoro-4'-methyl-2-biphenylyl)methoxy]phenyl}propanoic a cid
Smilesc1(ccc(cc1)OCc1c(ccc(c1)F)c1ccc(cc1)C)CCC(=O)O
Chemical Structure

Biological activities

TUG-891 is a potent and selective agonist for FFA4. The pIC50 of TUG-891 against TNF secretion in RAW264.7 cells is 5.86 μM. TUG-891 inhibits ERK phosphorylation in HT-29 cells with pEC50 of 5.13 μM. TUG-891 displays greater potency at mFFA1 with pEC50 of 5. 92 μM than hFFA1 with pEC50 of 4.76 μM. In vitro, TUG-891 both stimulates insulin-independent glucose uptake in 3T3-L1 cells and inhibits LPS-induced TNF secretion from RAW264.7 cells.[1]

References

[1] Hudson B D, Shimpukade B, Mackenzie A E, et al. The Pharmacology of TUG-891, a Potent and Selective Agonist of the Free Fatty Acid Receptor 4 (FFA4/GPR120), Demonstrates Both Potential Opportunity and Possible Challenges to Therapeutic Agonism. Molecular pharmacology. 2013, 84 (5): 710-725.

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KareBayTM provides scientists and clinicians with a wide range of biotechnological products and science lab supplies for chemical research and analyzing life processes. KareBay's extensive capabilities include commercializing reagents and kits, manufacturing biotech products and providing contract research services to organizations worldwide. Our many global labs, offices, and business partners enable KareBay to extend its products and services to its customer base around the world.

Our products are used for research, laboratory and further evaluation purposes. They are not for human use.
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