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KP1744 WP9QY, TNF - alpha Antagonist 1 mg $127

Product Information

Product NameWP9QY, TNF - alpha Antagonist
Purity% Peak Area By HPLC ≥ 95%
Molecular Weight 1226.4
Storage-20°C
Sequence
(One-Letter Code)
YCWSQYLCY (Disulfide bridge: 2-8)
Sequence
(Three-Letter Code)
H - Tyr - Cys - Trp - Ser - Gln - Tyr - Leu - Cys - Tyr - OH (Disulfide bridge: 2 - 8)
DescriptionThis cyclic peptide is designed to mimic the most critical tumor necrosis factor (TNF) recognition loop on TNF receptor I. It prevents interactions of TNF with its receptor. This TNF antagonist is a useful template for the development of small molecular inhibitors to prevent both inflammatory bone destruction and systemic bone loss in rheumatoid arthritis.
ReferencesSaito, H. et al. Arthritis Rheum. 56, 1164 (2007).
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