The cell cycle, also referred to as the cell-division cycle, is a series of events that occur in a cell that leads to its division and duplication (replication). The cell cycle is divided into five phases: the gap in DNA replication (G1), DNA synthesis phase (S), the gap after DNA replication (G2), mitosis phase (M) and the quiescent phase (G0). The ability to identify cell cycle position through DNA content analysis is critical to investigating cell cycle–regulated protein expression and assessing perturbations in cell cycle progression. The cell cycle encompasses three important targets to investigate its function in human disease. These targets are mitogen signaling cascades, cell cycle checkpoints and cyclin / CDK complexes. Mitogen signaling cascades include the growth factor and MAPK family and its kinases. Inhibitors of mitogen signaling cascades have been applied to the treatment of chronic myelogenous leukemia (CML), gastrointestinal stromal tumors and rheumatoid arthritis . Cell cycle checkpoints are important regulatory pathways in the control of cell cycle conversions and DNA replication  . Checkpoint pathway inhibitors serve as potential drug intervention agents in cancer chemotherapy. Cyclin / CDK complexes play a key role in controlling the replication of centrosomes and DNA in interphase and mitosis  . The role of CDKs in the cell cycle is increasingly elevating them as attractive drug targets, and the CDK inhibitors have been deployed therapeutically in the treatment of neurological diseases.
Reference Learn More
 Gray N S, Wodicka L, Thunnissen A M W H, et al. Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors[J]. Science, 1998, 281(5376): 533-538.
 Elledge S J. Cell cycle checkpoints: preventing an identity crisis[J]. Science, 1996, 274(5293): 1664-1672.
 Murray A W. Recycling the cell cycle: cyclins revisited[J]. Cell, 2004, 116(2): 221-234.
 Orlando D A, Lin C Y, Bernard A, et al. Global control of cell-cycle transcription by coupled CDK and network oscillators[J]. Nature, 2008, 453(7197): 944-947.
How to get started
Please download Catalog Order Form and contact us with your requests firstname.lastname@example.org and we will supply you with a detailed quote as soon as possible(you can leave us a message here). This process usually takes between 24 and 48 hours. The quote will include an estimated price as well as the time required to complete the project. All inquiries and subsequent projects are handled in the strictest confidence and will be backed up by a confidentiality agreement if desired.