Nuclear-Factor kappa B (NF-kB) is an inducible transcription factor of the Rel family, sequestered in the cytoplasm by the IkB family of proteins. NF-kB exists in several dimeric forms, but the p50/p65 heterodimer is the predominant one. Activation of NF-kB by a range of physical, chemical, and biological stimuli leads to phosphorylation and proteasome dependent degradation of IkB, leading to the release of free NF-kB.It is important in DAN binding,human disease,such as cancer,AUDS(HIV-1),Ageing,headaches,catabolic disorder ect and inflammatory diseases which include rheumatoid arthritis, atherogenesis, multiple,sclerosis, chronic inflammatory demyelinating, polyradiculoneuritis, asthma, inflammatory bowel disease etc.and Viral Diseases and Neurodegenerative Disorders
Recent studies show that The influences of nuclear factor-κB (NF-κB) gene silencing on the proliferation of gastric cancer SGC-7901 cells exposed to hypoxia and its possible mechanism were investigated. In SGC-7901 cells exposed to hypoxic conditions, there might be an interaction between HIF-1α and NF-κB. The suppression of NF-κB expression could inhibit the proliferative ability of gastric cancer SGC-7901 cells under hypoxic conditions via down-regulation of HIF-1α and PLD-1 expressions.
Many viruses can hijack the host cell NF-κB as part of their life cycle, diverting NF-κB immune regulatory functions to favor their replications.
Recent progress in the field of nuclear I κ Bs has provided important insights into the transcriptional regulation of inflammatory cytokines controlled by NF- κ B. Nuclear I κ Bs may contribute to the epigenetic modulation of gene loci for optimal activation and transcriptional silencing.A wide variety of environmental cues, including inflammatory cytokines, ligands for pattern recognition receptors and endogenous danger signals, activate the inducible transcription factor nuclear factor-κB (NF-κB), which is a central regulator of inflammatory and immune responses. Excessive activation of NF-κB results in the development of severe diseases, such as chronic inflammatory disorders, autoimmune diseases and cancer.
