5-fluorouracil Inhibitor CAS No. 51-21-8

Cat. No.	Name	Size	Price	Add Cart
KI0921	5-fluorouracil	25 mg	$80
KI0921	5-fluorouracil	100 mg	$200

Chemical Characteristic

Product Name	5-fluorouracil
Synonyms	Efudex
CAS No.	51-21-8
Molecular Weight	130.08
Formula	C₄H₃FN₂O₂
Chemical Structure

Biological activities

5-fluorouracil is a thymidylate synthase inhibitor. The IC50 of 5-fluorouracil is 24 µM against human colon carcinoma cell line.^[1] 5-fluorouracil up-regulates FasR expression on melanoma cells.^[2] The combination of 5-fluorouracil with selumetinib significantly decreases clonogenic survival compared with either agent alone.^[3] In vitro, 5-FU time- and dose-dependently affects cell proliferation and survival. ^[4] In vivo, the combination of piplartine with 5-fluorouracil leads to a higher tumor growth inhibition.^[5]

References

[1] Johnston PG, et al. The cellular interaction of 5-fluorouracil and cisplatin in a human colon carcinoma cell line. Eur J Cancer. 1996, 32A(12): 2148-2154. 閵嗏偓閵嗏偓 [2] Yang S, et al. Treatment of melanoma with 5-fluorouracil or dacarbazine in vitro sensitizes cells to antigen-specific CTL lysis through perforin/granzyme- and Fas-mediated pathways. J Immunol. 2004, 172(7): 4599-4608. 閵嗏偓閵嗏偓 [3] Urick ME, et al. Enhancement of 5-fluorouracil-induced in vitro and in vivo radiosensitization with MEK inhibition. Clin Cancer Res. 2011, 17(15): 5038-5047. 閵嗏偓閵嗏偓 [4] Huhtala A, et al. The effects of 5-fluorouracil on ocular tissues in vitro and in vivo after controlled release from a multifunctional implant. Invest Ophthalmol Vis Sci. 2009, 50(5): 2216-2223. 閵嗏偓閵嗏偓 [5] Bezerra DP, et al. In vitro and in vivo antitumor effect of 5-FU combined with piplartine and piperine. J Appl Toxicol. 2008, 28(2): 156-163. 閵嗏偓閵嗏偓

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