Home
Services
Organic Synthesis
Peptide Synthesis
Antibody Production
Protein Expression
Bioconjugation Service
Immunoassay Service
Molecular Biology Services
Oligonucleotides Synthesis
RNA Synthesis Service
Polymers & Contract Manufacturing
cGMP Peptide Synthesis Services
cGMP Organic Synthesis Services
Products
Small Molecule Inhibitors and Antagonist
Bioactive Compounds and Agonist
Primary Antibodies
Catalog Peptides
Amino Acids Derivatives
Reagents
Fluorescent dyes
Intermediates
PCR
Proteasomes and Enzymes
Enzyme substrate
Nucleotides
Promotions
Customer Support
About Us
Site Map
Contact Us
Small Molecule Inhibitors and Antagonist
Anti-virus
Cell Cycle
DMPK/Tox
Endocrinology
Epigenetics
GPCR/G-protein
Mitogen-activated Protein Kinases (MAPK)
PI3K/Akt/mTOR
Proteases/Proteasome
Protein Tyrosine Kinases (PTK)
Stem Cells
TGF-Beta/Smad
Transporter
Others
Cat. No. Name Size Price Add Cart
KI1046Acipimox50 mg$154
Acipimox100 mg$272

Chemical Characteristic

Product NameAcipimox
CAS No.51037-30-0
Molecular Weight 154.12
FormulaC6H6N2O3
Chemical Name5-Methylpyrazine-2-carboxylic acid 4-oxide
Smilesc1(cn(c(cn1)C)O)C(=O)O
Chemical Structure

Biological activities

Acipimox is a niacin derivative used as a hypolipidemic agent. Acipimox inhibits the production of triglycerides by the liver and the secretion of VLDL, which leads indirectly to a modest reduction in LDL and increase in HDL. For cells isolated from normal animals, acipimox stimulates leptin release to a similar extent compared to nicotinic acid and insulin. Co-incubation of acipimox with norepinephrine or dibutyryl cAMP diminishes the stimulatory effects on leptin release, in parallel with increased lipolysis.[1] Acipimox inhibits the lipolytic rate stimulated by adenosine deaminase in a concentration-dependent manner in epididymal adipocytes isolated from Wistar rats. Acipimox also diminishes the intracellular cyclic AMP level produced by isoproterenol in the presence of adenosine deaminase in a concentration-dependent manner.[2] Acipimox may reduce triglyceride synthesis by decreasing non-esterified fatty acid availability from adipocytes. In vivo, acipimox treatment decreases basal glycerol release in subcutaneous adipose tissue.[3]

Protocols

In vivo: Acipimox is dissolved in distilled water.[4]

References

[1] Wang-Fisher YL, et al. Acipimox stimulates leptin production from isolated rat adipocytes. J Endocrinol. 2002, 174(2): 267-272.
[2] Christie AW, et al. Mechanism of anti-lipolytic action of acipimox in isolated rat adipocytes. Diabetologia. 1996, 39(1): 45-53.
[3] Flechtner-Mors M, et al. Effects of acipimox on the lipolysis rate in subcutaneous adipose tissue of obese subjects. Diabetes Metab Res Rev. 2001, 17(5): 387-390.
[4] Lovisolo PP, et al. Pharmacological profile of a new antilipolytic agent: 5-methyl-pyrazine-2-carboxylic acid 4-oxide (acipimox) (1) II - Antilipolytic and blood lipid lowering activity. Pharmacol Res Commun. 1981, 13(2): 163-174.

Please click here to fill online order form, and we will make sure to supply you product with detail information. This process usually takes between 24 to 48 hours, depending on products stock avaliability. All inquires and subsequent projects are handled in the strictest confidence and will be backed by a confidentiality agreement if required.
KareBayTM provides scientists and clinicians with a wide range of biotechnological products and science lab supplies for chemical research and analyzing life processes. KareBay's extensive capabilities include commercializing reagents and kits, manufacturing biotech products and providing contract research services to organizations worldwide. Our many global labs, offices, and business partners enable KareBay to extend its products and services to its customer base around the world.

Our products are used for research, laboratory and further evaluation purposes. They are not for human use.
About
KareBayTM Biochem
Sitemap
Blog
Custom Services
Organic Synthesis
Peptide Synthesis
Antibody Production
Protein Expression
Bioconjugation Service
Immunoassry Service
Molecular Biology Services
Oligonucleotides Synthesis
RNA Synthesis Service
cGMP Peptide Synthesis Services
cGMP Organic Synthesis Services
Biochemical Products
Small Molecule Inhibitors
Bioactive Compounds
Primary Antibodies
Peptides
Amino Acids
Reagents
Fluorescent dyes
Intermediates
PCR
Contact Us
KareBayTM Biochem, Inc.
11 Deer Park Drive, Suite 102A
Monmouth Junction, NJ 08852
Telephone
: 732-823-1545

Fax
: 732-823-1349
product@karebaybio.com
service@karebaybio.com
support@karebaybio.com
Follow Us
Follow Karebay on LinkedinFollow IMAGING on Twitter Google+ Facebook