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KI0914Adenosine50 mg$154

Chemical Characteristic

Product NameAdenosine
SynonymsDifferin
CAS No.58-61-7
Molecular Weight 267.24
FormulaC10H13N5O4
Chemical Structure

Biological activities

Adenosine is a purine nucleoside comprising a molecule of adenine attached to a ribose sugar molecule (ribofuranose) moiety via a β-N9-glycosidic bond. Adenosine is an endogenous neuroprotective metabolite that through activation of the A1 receptor results in reduction of neuronal damage following cerebral ischemia. Adenosine is able to protect neurons from chick embryo cerebral hemispheres against hypoxic damage.[1] Adenosine (50 µM) causes a 10-15 mV hyperpolarization of CA3 cells, as well as a 75-100 % decrease in the amplitude of excitatory and polysynaptic inhibitory postsynaptic potentials (EPSPs and IPSPs). Adenosine also reduces the amplitude of isolated EPSPs, elicited after blocking GABAA receptors and reducing subsequent epileptic bursts with excitatory amino acid receptor antagonists. Adenosine (0.03-1 µM) reduces the frequency of spontaneous epileptiform bursting produced by bicuculline.[2] In a rat model of unilateral common carotid artery occlusion coupled with hypoxia, adenosine activates the neurotrophic kinase Akt/PKB.[3]

Protocols

In vivo: Adenosine is dissolved in saline.[4]

References

[1] Krieglstein J, et al. Vinpocetine increases the neuroprotective effect of adenosine in vitro. Eur J Pharmacol. 1991, 205(1): 7-10. 閵嗏偓閵嗏偓
[2] Thompson SM, et al. Comparison of the actions of adenosine at pre- and postsynaptic receptors in the rat hippocampus in vitro. J Physiol. 1992, 451: 347-363. 閵嗏偓閵嗏偓
[3] Gervitz LM, et al. Adenosine-mediated activation of Akt/protein kinase B in the rat hippocampus in vitro and in vivo. Neurosci Lett. 2002, 328(2): 175-179. 閵嗏偓閵嗏偓
[4] Agmon Y, et al. Disparate effects of adenosine A1- and A2-receptor agonists on intrarenal blood flow. Am J Physiol. 1993, 265(6 Pt 2): F802-806. 閵嗏偓閵嗏偓

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