Home
Services
Organic Synthesis
Peptide Synthesis
Antibody Production
Protein Expression
Bioconjugation Service
Immunoassay Service
Molecular Biology Services
Oligonucleotides Synthesis
RNA Synthesis Service
Polymers & Contract Manufacturing
cGMP Peptide Synthesis Services
cGMP Organic Synthesis Services
Products
Small Molecule Inhibitors and Antagonist
Bioactive Compounds and Agonist
Primary Antibodies
Catalog Peptides
Amino Acids Derivatives
Reagents
Fluorescent dyes
Intermediates
PCR
Proteasomes and Enzymes
Enzyme substrate
Nucleotides
Promotions
Customer Support
About Us
Site Map
Contact Us
Small Molecule Inhibitors and Antagonist
Anti-virus
Cell Cycle
DMPK/Tox
Endocrinology
Epigenetics
GPCR/G-protein
Mitogen-activated Protein Kinases (MAPK)
PI3K/Akt/mTOR
Proteases/Proteasome
Protein Tyrosine Kinases (PTK)
Stem Cells
TGF-Beta/Smad
Transporter
Others
Cat. No. Name Size Price Add Cart
KI0846Alendronate sodium2 mg$112
Alendronate sodium5 mg$192
Alendronate sodium25 mg$592

Chemical Characteristic

Product NameAlendronate sodium
SynonymsMK 217, Fosamax
CAS No.121268-17-5
Molecular Weight 325.12
FormulaC4H12NO7P2.Na.3H2O
Chemical Structure

Biological activities

Alendronate sodium, a nitrogen-containing bisphosphonate, is a potent inhibitor of bone resorption used for the treatment and prevention of osteoporosis. Alendronate sodium inhibits the isoprenoid biosynthesis pathway and interferes with protein prenylation. Alendronate sodium inhibits recombinant human farnesyl diphosphate synthase with an IC50 of 460 nM. In osteoclasts, alendronate sodium inhibits the incorporation of [3H] mevalonolactone into proteins of 18-25 kDa and into nonsaponifiable lipids, including sterols.[1] Alendronate sodium induces apoptosis in the mouse macrophage cell line J774. Alendronate sodium also inhibits murine osteoclast formation in culture.[2] In adult hound dogs experiment in vivo, locally applied alendronate sodium results in significantly increased amounts of bone in the peripheral area with both HA and TMP implants.[3] Furthermore, alendronate sodium also appears to inhibit or delay bone fusion in a rabbit model.[4]

Protocols

In vivo: Alendronate sodium is dissolved in saline.[4]

References

[1] Bergstrom JD, et al. Alendronate is a specific, nanomolar inhibitor of farnesyl diphosphate synthase. Arch Biochem Biophys. 2000, 373(1): 231-241.
[2] Fisher JE, et al. Alendronate mechanism of action: geranylgeraniol, an intermediate in the mevalonate pathway, prevents inhibition of osteoclast formation, bone resorption, and kinase activation in vitro. Proc Natl Acad Sci U S A. 1999, 96(1): 133-138. 閵嗏偓閵嗏偓
[3] Meraw SJ, et al. Qualitative analysis of peripheral peri-implant bone and influence of alendronate sodium on early bone regeneration. J Periodontol. 1999, 70(10): 1228-1233. 閵嗏偓閵嗏偓
[4] Lehman RA Jr, et al. The effect of alendronate sodium on spinal fusion: a rabbit model. Spine J. 2004, 4(1): 36-43. 閵嗏偓閵嗏偓

Please click here to fill online order form, and we will make sure to supply you product with detail information. This process usually takes between 24 to 48 hours, depending on products stock avaliability. All inquires and subsequent projects are handled in the strictest confidence and will be backed by a confidentiality agreement if required.
KareBayTM provides scientists and clinicians with a wide range of biotechnological products and science lab supplies for chemical research and analyzing life processes. KareBay's extensive capabilities include commercializing reagents and kits, manufacturing biotech products and providing contract research services to organizations worldwide. Our many global labs, offices, and business partners enable KareBay to extend its products and services to its customer base around the world.

Our products are used for research, laboratory and further evaluation purposes. They are not for human use.
About
KareBayTM Biochem
Sitemap
Blog
Custom Services
Organic Synthesis
Peptide Synthesis
Antibody Production
Protein Expression
Bioconjugation Service
Immunoassry Service
Molecular Biology Services
Oligonucleotides Synthesis
RNA Synthesis Service
cGMP Peptide Synthesis Services
cGMP Organic Synthesis Services
Biochemical Products
Small Molecule Inhibitors
Bioactive Compounds
Primary Antibodies
Peptides
Amino Acids
Reagents
Fluorescent dyes
Intermediates
PCR
Contact Us
KareBayTM Biochem, Inc.
11 Deer Park Drive, Suite 102A
Monmouth Junction, NJ 08852
Telephone
: 732-823-1545

Fax
: 732-823-1349
product@karebaybio.com
service@karebaybio.com
support@karebaybio.com
Follow Us
Follow Karebay on LinkedinFollow IMAGING on Twitter Google+ Facebook