Alprostadil Inhibitor CAS No. 745-65-3

Cat. No.	Name	Size	Price
KI3720	Alprostadil	5 mg	$510
	Alprostadil	10 mg	$714
	Alprostadil	50 mg	$970
	Alprostadil	100 mg	$1140

Chemical Characteristic

Product Name	Alprostadil
CAS No.	745-65-3
Molecular Weight	354.48
Formula	C₂₀H₃₄O₅
Chemical Name	11,15-dihydroxy-9-oxo-, (11?,13E,15S)-prost-13-en-1-oic acid
Smiles	C(=O)(CCCCCCC1C(=O)C[C@H]([C@@H]1/C=C/[C@H](CCCCC)O)O)O
Chemical Structure

Biological activities

Alprostadil is produced endogenously and causes vasodilation by means of a direct effect on vascular and ductus arteriosus (DA) smooth muscle, preventing or reversing the functional closure of the DA that occurs shortly after birth ^[1]. This results in increased pulmonary or systemic blood flow in infants. In infants, it is used for palliative, not definitive, therapy to temporarily maintain the patency of the ductus arteriosus until corrective or palliative surgery can be performed in neonates who have congenital heart defects and who depend upon the patent ductus for survival [^[2]. In vivo, it can be used by 5-10ug/day in adults ^[3].

References

[1] Luo C, Li T, Zhang C, et al. Therapeutic Effect of Alprostadil in Diabetic Nephropathy: Possible Roles of Angiopoietin-2 and IL-18. Cell Physiol Biochem. 2014, 34(3):916-928. [2] Inoue H, Aihara M, Tomioka M, et al. Specific enhancement of vascular endothelial growth factor (VEGF) production in ischemic region by alprostadil--potential therapeutic application in pharmaceutical regenerative medicine. J Pharmacol Sci. 2013,122(2):158-161. [3] Costa P, Potempa AJ. Intraurethral alprostadil for erectile dysfunction: a review of the literature. Drugs. 2012, 72(17):2243-2254.

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