ALT711 Inhibitor CAS No. 341028-37-3

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Chemical Characteristic

Product Name	ALT711
CAS No.	341028-37-3
Molecular Weight	267.77
Formula	C₁₃H₁₄ClNOS
Chemical Name	4,5-Dimethyl-3-(2-oxo-2-phenylethyl)thiazolium chloride
Smiles	s1cn(c(c1C)C)CC(=O)c1ccccc1 Cl
Chemical Structure
Documents	COA HNMR_ALT -711 HPLC MS

Biological activities

ALT711 was the first drug candidate to be clinically tested for the purpose of breaking the crosslinks caused by advanced glycation endproducts (AGEs), thereby reversing one of the main mechanisms of aging ^[1]. Through this effect Alagebrium is designed to reverse the stiffening of blood vessel walls that contributes to hypertension and cardiovascular disease, as well as many other forms of degradation associated with protein crosslinking. Alagebrium has proven effective in reducing systolic blood pressure and providing therapeutic benefit for patients with diastolic heart failure. In vitro, the chelating activity of ALT711 on copper-catalyzed oxidation of AA is considerable, and IC50 is 1.92 ? 0.20 mM ^[2].

References

[1] Lee JY, Oh JG, Kim JS, et al. Effects of chebulic acid on advanced glycation endproducts-induced collagen cross-links. Biol Pharm Bull. 2014;37(7):1162-1167. [2] Brodeur MR, Bouvet C, Bouchard S, et al. Reduction of advanced-glycation end products levels and inhibition of RAGE signaling decreases rat vascular calcification induced by diabetes. PLoS One. 2014, 9(1):e85922.

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