Home
Services
Organic Synthesis
Peptide Synthesis
Antibody Production
Protein Expression
Bioconjugation Service
Immunoassay Service
Molecular Biology Services
Oligonucleotides Synthesis
RNA Synthesis Service
Polymers & Contract Manufacturing
cGMP Peptide Synthesis Services
cGMP Organic Synthesis Services
Products
Small Molecule Inhibitors and Antagonist
Bioactive Compounds and Agonist
Primary Antibodies
Catalog Peptides
Amino Acids Derivatives
Reagents
Fluorescent dyes
Intermediates
PCR
Proteasomes and Enzymes
Enzyme substrate
Nucleotides
Promotions
Customer Support
About Us
Site Map
Contact Us
Small Molecule Inhibitors and Antagonist
Anti-virus
Cell Cycle
DMPK/Tox
Endocrinology
Epigenetics
GPCR/G-protein
Mitogen-activated Protein Kinases (MAPK)
PI3K/Akt/mTOR
Proteases/Proteasome
Protein Tyrosine Kinases (PTK)
Stem Cells
TGF-Beta/Smad
Transporter
Others
Cat. No. Name Size Price Add Cart
KI0917Amiloride hydrochloride50 mg$155.2

Chemical Characteristic

Product NameAmiloride hydrochloride
SynonymsMidamor, Colectril, Amipramizide, Guanamprazine hydrochloride
CAS No.2016-88-8
Molecular Weight 266.09
FormulaC6H9Cl2N7O
Chemical Structure

Biological activities

Amiloride hydrochloride is a commonly used inhibitor of Na+/H+ exchange. Amiloride hydrochloride is a potassium-sparing diuretic, used in the management of hypertension and congestive heart failure. The IC50 value for amiloride is 50 nM in the baboon bronchus and 500 nM in the rat colon. Amiloride (25 µM) inhibits the short-circuit current 21% in the rat trachea, 63% in the baboon bronchus, and 90% in the rat colon.[1] Amiloride hydrochloride inhibits TRPP3-mediated Ca2+-activated currents with IC50 value of 143 µM.[2] In psychophysical experiments, amiloride hydrochloride blocks the direct infusion of acidic solutions (pH 閳?6.0) into human skin which causes localized pain. Under more severe acidification (pH 5.0) amiloride hydrochloride is less effective in reducing acid-evoked pain.[3] Furthermore, amiloride hydrochloride potently inhibits murine tissue swelling and inflammation in response to contact sensitizing agents and ultraviolet radiation.[4]

Protocols

In vivo: Amiloride hydrochloride is dissolved in water. [5]

References

[1] Legris GJ, et al. Inhibition of amiloride-sensitive sodium conductance by indoleamines. Proc Natl Acad Sci U S A. 1982, 79(6): 2046-2050.
[2] Dai XQ, et al. Inhibition of TRPP3 channel by amiloride and analogs. Mol Pharmacol. 2007, 72(6): 1576-1585. 閵嗏偓閵嗏偓
[3] Ugawa S, et al. Amiloride-blockable acid-sensing ion channels are leading acid sensors expressed in human nociceptors. J Clin Invest. 2002, 110(8): 1185-1190.
[4] Gallo RL, et al. Inhibition of allergic contact dermatitis and ultraviolet radiation-induced tissue swelling in the mouse by topical amiloride. Arch Dermatol. 1989, 125(4): 502-506. 閵嗏偓閵嗏偓
[5] Junor RW, et al. A novel role for cyclic nucleotide-gated cation channels in lung liquid homeostasis in sheep. J Physiol. 1999, 520 Pt 1: 255-260. 閵嗏偓閵嗏偓

Please click here to fill online order form, and we will make sure to supply you product with detail information. This process usually takes between 24 to 48 hours, depending on products stock avaliability. All inquires and subsequent projects are handled in the strictest confidence and will be backed by a confidentiality agreement if required.
KareBayTM provides scientists and clinicians with a wide range of biotechnological products and science lab supplies for chemical research and analyzing life processes. KareBay's extensive capabilities include commercializing reagents and kits, manufacturing biotech products and providing contract research services to organizations worldwide. Our many global labs, offices, and business partners enable KareBay to extend its products and services to its customer base around the world.

Our products are used for research, laboratory and further evaluation purposes. They are not for human use.
About
KareBayTM Biochem
Sitemap
Blog
Custom Services
Organic Synthesis
Peptide Synthesis
Antibody Production
Protein Expression
Bioconjugation Service
Immunoassry Service
Molecular Biology Services
Oligonucleotides Synthesis
RNA Synthesis Service
cGMP Peptide Synthesis Services
cGMP Organic Synthesis Services
Biochemical Products
Small Molecule Inhibitors
Bioactive Compounds
Primary Antibodies
Peptides
Amino Acids
Reagents
Fluorescent dyes
Intermediates
PCR
Contact Us
KareBayTM Biochem, Inc.
11 Deer Park Drive, Suite 102A
Monmouth Junction, NJ 08852
Telephone
: 732-823-1545

Fax
: 732-823-1349
product@karebaybio.com
service@karebaybio.com
support@karebaybio.com
Follow Us
Follow Karebay on LinkedinFollow IMAGING on Twitter Google+ Facebook